A tablet containing 2-8% w/w API is likely to use which of the following as a disintegrant?

In tablet formulation, disintegrants are crucial for ensuring the tablet breaks down appropriately in the gastrointestinal tract, allowing the active pharmaceutical ingredient (API) to be absorbed effectively. Sodium Starch Glycolate is a commonly used disintegrant, particularly effective at low concentrations of API, such as 2-8% w/w. This substance promotes swelling upon contact with fluids, which helps to disrupt the tablet's structure and enhances the dispersion of the API for better dissolution.

The suitable concentration of the API, such as the 2-8% range mentioned, makes Sodium Starch Glycolate an ideal choice due to its strong ability to facilitate disintegration while not adversely affecting other components in the tablet formulation. Its unique properties allow it to work well in various conditions, and it is particularly beneficial when the API content is relatively low, as it maintains the integrity of the tablet without compromising the overall formulation.

Other substances listed, like magnesium stearate, are primarily used as lubricants rather than disintegrants. Citric acid, while it can potentially enhance solubility or act as a buffering agent, does not function primarily to disintegrate tablets in the context presented. Talc is commonly used as an inert filler or to aid in flow