Are compressed solids the most common matrix for extended-release systems?

Compressed solids are indeed the most common matrix for extended-release systems. This is primarily because their solid nature allows for a controlled and sustained release of the active pharmaceutical ingredient over an extended period. The matrix can be designed using various materials that control the diffusion rate of the drug or the dissolution rate, which are crucial factors in achieving the desired release profile.

In addition, the production of compressed solid dosage forms, such as tablets, is well-established and allows for consistent quality, stability, and ease of handling during manufacturing and distribution. These forms can be engineered with various excipients that support extended-release characteristics, such as hydrophilic polymers that swell or form gels upon contact with fluids.

While other forms of drug delivery exist, like liquid formulations or other solid forms (e.g., granules), they do not match the reliability and widespread use of compressed solids for extended-release applications. Thus, asserting that compressed solids are the most common matrix for extended-release systems accurately reflects current practices in pharmaceutical formulation.