In compounding, what is spatulation used for?

Spatulation is a technique employed in compounding that focuses on the mixing of small quantities of powders to achieve a uniform consistency and distribution. This method typically involves the use of a spatula on a smooth surface, such as a glass slab or an ointment tile, which allows for efficient blending of the powders without introducing excessive air or causing excessive friction, which can lead to degradation or unwanted heating.

In this context, spatulation is particularly useful for integrating powders of varying particle sizes or for incorporating a small quantity of one ingredient into a larger bulk of powders. It's ideal when working with potent substances where precise dosing and uniformity are crucial. This technique is different from bulk mixing methods, which are intended for larger volumes where other forms of mixing might be more appropriate, such as trituration or mechanical mixers.

The other methods highlighted are differentiated by their specific uses; for instance, grinding substances into powder pertains more to trituration, which involves reducing the size of solid particles. Coating tablets falls into a different category involving different techniques altogether that are not related to the mixing of powders. Thus, the focus on small quantities for spatulation aligns perfectly with its purpose and application in compounding.