In terms of physical state, hard gelatin capsules typically contain what, while soft gelatin capsules contain what?

Hard gelatin capsules are designed to hold solid medications, such as powders or granules, which enables efficient delivery of active pharmaceutical ingredients. The structure of a hard gelatin capsule consists of two separate parts, allowing for the encapsulation of solid formulations. This format is advantageous for controlled dosage and consistent release of the active compound.

On the other hand, soft gelatin capsules are typically filled with liquids or semi-solid substances, thus their design accommodates the encapsulation of a range of formulations, including oils, suspensions, and some types of active ingredients that are better delivered in a liquid state. The soft outer shell is more pliable than that of hard capsules, facilitating the inclusion of these liquid formulations.

This distinction in the physical state of the contents—solids for hard gelatin capsules and liquids for soft gelatin capsules—highlights how the design and intended use of these dosage forms are tailored to specific pharmaceutical needs, allowing for various routes of administration and drug release profiles.