Orally disintegrating tablets (ODTs) usually contain which ingredient to aid in rapid disintegration?

Orally disintegrating tablets (ODTs) are designed to dissolve quickly in the mouth without the need for water. The primary ingredient that facilitates this rapid disintegration is super-disintegrants. These substances are specifically formulated to promote the breakdown of the tablet matrix upon exposure to moisture or saliva, thereby enhancing the rate at which the tablet disintegrates.

Super-disintegrants work by swelling and creating channels within the tablet, which accelerates the disintegration process. Common examples of super-disintegrants include sodium starch glycolate, crosprovide, and povidone. Their unique properties are crucial in ensuring that ODTs provide quick relief as they dissolve rapidly, allowing for the swift release of the active pharmaceutical ingredient.

In contrast, ingredients such as binders primarily serve to hold the tablet together during manufacturing and are not intended to expedite disintegration. Preservatives are added to prevent microbial growth but do not affect the disintegration time. Fillers are often used to add bulk to the tablet but also do not contribute to the rapid disintegration characteristic of ODTs.