Tablets that contain multiple pellets, each with its own controlled release mechanism are known as what?

Tablets that contain multiple pellets, each with its own controlled release mechanism, are referred to as a multi-unit pellet system. This formulation approach allows for a more uniform drug release profile, as the individual pellets can be designed to release their drug content at varying rates and times. As a result, this system can provide an extended duration of action and better control over the pharmacokinetics of the drug.

The use of multiple pellets enhances the dispersion of drug particles in the gastrointestinal tract, leading to improved absorption characteristics and reduced peak-trough fluctuations in drug plasma levels. This multitudes of release profiles from individual pellets allows for customized dosing regimens that can better meet patient needs, especially in complex therapeutic situations.

Other options such as controlled release tablets refer to a broader category of tablets that might not use pellets or can use a single pellet format. Layered tablets typically consist of layers of different ingredients rather than separate pellets, and combination release tablets usually refer to formulations combining both immediate and controlled release features but may not necessarily involve pellets. Therefore, the most precise term for tablets with multiple pellets, each accommodating distinct release mechanisms, is the multi-unit pellet system.