True or False: Compression coating can be achieved when moisture is present.

Compression coating is a method used in pharmaceutical formulations to create a barrier around a core tablet, often to protect the drug from environmental factors or to control the release of the active ingredient. This process typically involves the application of a coating layer around the core using specific materials that can be compressed together.

When moisture is present during the compression coating process, it can have detrimental effects. The presence of moisture can lead to issues such as the formation of a sticky mass, which compromises the integrity of the coating and potentially alters the physical properties of the formulation. Moisture can also affect the interaction between excipients used in the coating, leading to suboptimal adhesion and other problems related to the dissolution and release profiles of the drug.

In contrast, compression coating is most effectively performed under dry conditions to ensure that the materials are able to produce a solid, well-adhered coating. This condition helps maintain the desired characteristics of the coating and overall formulation. Therefore, stating that compression coating can be achieved when moisture is present is not accurate, as moisture generally disrupts the process.