What are the physical properties of pellets produced by extrusion-spheronization?

The physical properties of pellets produced by extrusion-spheronization typically include low friability and smooth surfaces. During the extrusion-spheronization process, a wet mass of powder is extruded to form cylindrical shapes which are then spheronized into rounded pellets. This process helps to create uniform, spherical pellets that are generally uniform in size and have an optimal surface finish.

Low friability indicates that the pellets have good mechanical integrity and can withstand handling and transport without breaking apart. Smooth surfaces reduce friction as well as potential aggregation during processing and storage, making these pellets ideal for further applications, such as in controlled-release formulations.

In contrast, other options describe characteristics that do not align with the expected outcomes of the extrusion-spheronization process. High friability and rough surfaces would suggest a lack of structural integrity and poor handling properties. High strength with irregular sizes does not accurately represent the uniformity achieved through the spheronization phase, which emphasizes shaping the pellets to consistent size and strength. Finally, low strength and irregular shapes would not be suitable for pellets intended for pharmaceutical applications, as they require specific mechanical properties to ensure effective delivery and performance.