What are the two most common techniques used in wet granulation?

High shear and fluidized bed wet granulation are considered the two most common techniques used in the wet granulation process due to their efficiency and effectiveness in producing granules with desirable properties. In high shear wet granulation, a binder solution is added to a powder mixture in a high-shear mixer, which generates intense agitation. This process leads to the formation of granules through the agglomeration of powder particles and ensures homogeneity, which is vital for consistent drug properties.

Fluidized bed wet granulation, on the other hand, involves the use of a fluidized bed granulator where air is passed through a wetted mass of powder. This technique evenly distributes the binder over the particles and promotes granule formation as the particles rise and collide, enhancing their growth and density. The granules produced have good flow characteristics and uniformity, making these techniques widely favored in the pharmaceutical industry for formulations that require reliable dosage forms and improved solubility.

Other choices mentioned do not represent the core methods typically employed in wet granulation. Low shear and cylindrical mixing, dry powder mixing and compression, as well as vibrational and planetary mixing, serve different purposes and are less common in the context of wet granulation specifically. These methods may be part of other