What is the correct sequence of operations in the tableting process?

The correct sequence of operations in the tableting process is foundational to producing a high-quality tablet. In this sequence, milling is typically the first step where the raw materials are reduced to a powder form. This is crucial for achieving uniformity in particle size, which affects both the flow properties and compressibility of the powder.

Blending follows milling, where the powdered ingredients are mixed to ensure uniform distribution of the active pharmaceutical ingredient (API) and excipients. This is key to ensuring consistent dosages in each tablet.

Granulation then comes into play, which may involve processes such as wet granulation or dry granulation. The goal of granulation is to improve the flowability and compressibility of the powder blend, creating granules that can be more easily compressed into tablets.

Re-blending, if required, ensures that any granulation process that might have altered blend uniformity is corrected by blending the granulated material once again.

Once a consistent and suitable blend is achieved, the granules are then compressed into tablets in the tableting step. This operation is critical for forming the tablets into their final shapes and ensuring they meet the required specifications for hardness and disintegration.

Finally, the tablets undergo coating, which serves various purposes, such as improving stability