What is the effect of high-pressure compaction in tableting?

High-pressure compaction in tableting plays a critical role in ensuring the appropriate formulation and integrity of tablets. The primary effect of this process is the consolidation of powder particles together, which leads to the formation of a solid and cohesive tablet. During high-pressure compaction, the applied force causes the powder particles to deform and rearrange, leading to improved bonding through mechanisms such as plastic deformation and mechanical interlocking. This results in tablets that have the desired hardness, durability, and dissolution characteristics, ultimately influencing their performance in drug delivery.

The other options, while mentioning different characteristics of tablets, do not relate to the fundamental effect of high-pressure compaction. For example, the process does not inherently affect the aroma, shelf-life, or color of the tablets, which are influenced by other formulation factors like excipients or environmental conditions. The primary focus of high-pressure compaction is the mechanical bonding of the powder particles to achieve the correct tablet form.