What is the function of glidants in powder mixtures?

Glidants serve a crucial role in enhancing the flow characteristics of powder mixtures by reducing interparticle interactions. These materials are added to powders to promote better flowability by minimizing friction and cohesion between particles. When powders are processed, especially in tablet manufacturing, poor flow can lead to inconsistent tablet weights and difficulties in achieving uniformity during compaction. Glidants, such as silica or talc, create a smoother surface on the particles and can help in promoting the movement of particles past one another, thereby improving the overall handling characteristics of the powder blend. This property is particularly important in ensuring that the final dosage form has consistent physical attributes and performance, making the use of glidants fundamental in pharmaceutical formulations.