What is the main purpose of milling in pharmaceutical processing?

The main purpose of milling in pharmaceutical processing is for particle-size reduction. This process involves breaking down larger particles into smaller, more uniform particle sizes, which can enhance the bioavailability of a drug, improve its dissolution rate, and ensure uniformity in the formulation. By reducing the size of the particles, milling increases the surface area available for absorption, which is critical for effective drug action.

Moreover, smaller particle sizes can improve the uniformity of the blend in a formulation, facilitate better mixing, and contribute to consistent dosing in tableting and capsule manufacturing processes. The reduction in particle size also plays a significant role in enhancing the flow characteristics of the powder, which is essential during the manufacturing processes.

Other options, such as blending active compounds or adding lubricants, are important processes in pharmaceutical manufacturing but do not directly relate to the initial and primary function of milling. Milling specifically targets the modification of particle size rather than altering color or integrating other components. Thus, the correct choice of particle-size reduction underscores its vital role in improving the efficiency and effectiveness of pharmaceutical products.