What is the most commonly used pelletization aid?

Microcrystalline cellulose is the most commonly used pelletization aid due to its favorable properties in enhancing the flow and compressibility of granulations during the pelletization process. It acts as a binder and filler, facilitating the formation of spherical pellets that maintain structural integrity and uniformity, which are crucial for both dosing accuracy and the efficiency of subsequent manufacturing processes.

Microcrystalline cellulose is particularly valued for its ability to enhance the physical characteristics of pellets, such as hardness, friability, and dissolution rates, making it ideal for use in the pharmaceutical industry. Additionally, it is relatively inert and does not interfere with the active ingredients, thus providing a stable matrix that can be used in various formulations.

Other options may serve specific roles in formulation or processing but do not match the widespread application and multifunctionality of microcrystalline cellulose in pelletization. For instance, while povidone can act as a binder, its primary role is often more focused on forming solution adhesives rather than providing the bulk and structural properties needed for pelletization. Starch also has applications as a binder or disintegrant but is less preferred due to variability in properties and functionality under different processing conditions. Sodium lauryl sulfate is primarily a surfactant and is not commonly used as a pellet