What is the primary use of plasticizers in pharmaceutical formulations?

The primary use of plasticizers in pharmaceutical formulations is to enhance the flexibility and workability of polymer-based materials, especially in coatings and films. Plasticizers reduce the glass transition temperature of polymers, which allows for easier application and manipulation of coatings on pharmaceutical products, such as tablets or capsules. This versatility is crucial during the coating process, as it helps achieve a uniform and smooth application, enhancing the overall performance of the formulation.

When implemented effectively, plasticizers can also help in controlling the release of the drug from the coating, thereby affecting the dissolution and bioavailability of the active pharmaceutical ingredient. This is particularly important in controlled-release formulations, where the coating must maintain its integrity until the desired release profile is achieved.

Enhancing stability or improving flow properties may be secondary benefits associated with the incorporation of plasticizers, but the primary focus remains on facilitating the coating application itself. Increasing the dissolution rate, while a relevant factor in formulation design, is not the main role of plasticizers. Their key function is to improve the physical handling and application of coating materials in pharmaceutical products.