What two factors of the disintegrant can influence capsule dissolution?

The correct answer highlights that both the type and concentration of the disintegrant play crucial roles in influencing the dissolution of capsules.

The type of disintegrant is significant because different materials have varying mechanisms and efficiencies in promoting disintegration. For instance, some disintegrants may swell upon contact with moisture, effectively breaking down the capsule contents, while others may facilitate disintegration through different physical or chemical interactions. The choice of disintegrant can significantly affect how quickly and thoroughly the active ingredient is released into the solution, impacting bioavailability.

Concentration is equally important, as the amount of disintegrant present can determine the speed and extent of disintegration. Too little disintegrant may lead to insufficient breakdown, delaying dissolution, while too much may lead to rapid disintegration that can affect the whole formulation’s stability and efficacy.

By considering these two factors together—type and concentration—formulators can optimize the performance of capsules to ensure proper drug release and absorption in the body.