When handling ODTs, which of the following actions should be avoided?

When handling orally disintegrating tablets (ODTs), it is crucial to maintain their integrity and functionality to ensure that they can dissolve properly in the mouth for effective medication delivery. Pressing the tablet through the blister can cause damage to the tablet itself, potentially leading to crumbling or breaking. This can impair the drug's ability to dissolve correctly, which could affect the therapeutic outcome by altering the release characteristics of the active ingredient. Thus, avoiding this practice is essential to maintaining the quality of ODTs.

In contrast, actions like cutting the tablet in half or dissolving it in hot water are discouraged because they can compromise the tablet's intended release profile or effectiveness. Storing ODTs in a cool place is generally acceptable, as it helps maintain stability, especially for temperature-sensitive drugs. Therefore, the correct action to avoid when handling ODTs relates to preserving their structural integrity and optimal performance, which is why pressing them through the blister should be avoided.