Which is a specific requirement for extrusion in tablet formulation?

In the context of tablet formulation, a specific requirement for extrusion is that the mass must be cohesive and possess plasticity, along with inherent fluidity. This characteristic is essential because, during the extrusion process, the material is forced through a die to form the desired shape. The cohesiveness ensures that the particles stick together, preventing the formation of weak or broken tablets, while plasticity allows the mass to be deformed under pressure without cracking.

Inherent fluidity is important because it facilitates the flow of the material through the extruder, aiding in the formation of uniform strands or pellets. The combination of these properties is crucial for achieving a consistent and stable product with the appropriate physical and mechanical characteristics necessary for tablet production.

While the other options touch on important aspects of the formulation process, they do not specifically capture the unique requirement that allows for effective extrusion. A finely powdered mass contributes to dissolution and other properties, but it is not exclusively necessary for the extrusion process. Similarly, while a binder is often used in formulations, a specific high percentage is not a universal requirement for extrusion methods. High-pressure mixing may be part of certain processes, but it is not inherently a requirement for successful extrusion itself.