Which of the following is NOT a benefit of multi-particulate dosage forms?

Multi-particulate dosage forms, which include granules, pellets, and microspheres, typically offer several advantages when it comes to drug delivery. One of their main benefits is greater bioavailability, as they can have enhanced solubility and absorption characteristics. They also allow for improved therapeutic flexibility by accommodating different dosing regimens, which can be particularly beneficial for drugs that require tailored dosing strategies.

Additionally, multi-particulate systems often lead to reduced production waste due to their uniformity and the precise control they offer during manufacturing. They are usually easier to formulate and scale up compared to traditional single-unit dosage forms, which can result in less waste during the production process.

In contrast, higher manufacturing complexity is often considered a disadvantage rather than a benefit. The formulation and production processes for multi-particulate dosage forms may require more advanced technology and control systems, thus increasing the complexity of manufacturing. While they offer many benefits, the need for specialized equipment and techniques can complicate production, making this option the correct choice as the one that does not align with the benefits of multi-particulate systems.